Aspirin and Omeprazole Tablets and Rifampin Capsules

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Talk to your doctor before using omeprazole together with rifAMPin. Combining these medications may reduce the blood levels and effects of omeprazole. Let your doctor know if your condition worsens during treatment with these medications. Your doctor may be able to prescribe alternative treatments that do not interact, or you may need a dose adjustment to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration with potent inducers of CYP450 2C19 and/or 3A4 may significantly decrease the plasma concentrations of omeprazole, which is primarily metabolized by these isoenzymes. In a study consisting of 12 healthy male subjects, administration of omeprazole in combination with St John's wort (300 mg three times daily for 14 days) decreased omeprazole peak plasma concentration (Cmax) and systemic exposure (AUC) in CYP450 2C19 poor metabolizers by 37.5% and 37.9%, respectively, and in extensive metabolizers by 49.6 % and 43.9%, respectively. The interaction is likely to also occur with esomeprazole, an enantiomer of omeprazole.

MANAGEMENT: The concomitant use of omeprazole or esomeprazole with St. John's wort or rifampin should generally be avoided.

Aspirin and Omeprazole Tablets

Generic Name: aspirin / omeprazole

Brand name: Yosprala

Synonyms: Aspirin and omeprazole, Aspirin and Omeprazole

What is Aspirin and Omeprazole Tablets?

Rifampin Capsules

Generic Name: rifampin

Brand name: Rifadin, Rifadin IV, Rimactane

Synonyms: Rifampin

What is Rifampin Capsules?