Aspirin, caffeine, and dihydrocodeine and Protonix (Pantoprazole Delayed-Release Granules)
Determining the interaction of Aspirin, caffeine, and dihydrocodeine and Protonix (Pantoprazole Delayed-Release Granules) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:One study has reported that coadministration of caffeine and aspirin lead to a 25% increase in the rate of appearance and 17% increase in maximum concentration of salicylate in the plasma. A significantly higher area under the plasma concentration time curve of salicylate was also reported when both drugs were administered together. The exact mechanism of this interaction has not been specified. Physicians and patients should be aware that coadministration of aspirin and caffeine may lead to higher salicylate levels faster.
- Yoovathaworn KC, Sriwatanakul K, Thithapandha A "Influence of caffeine on aspirin pharmacokinetics." Eur J Drug Metab Pharmacokinet 11 (1986): 71-6
Generic Name: aspirin / caffeine / dihydrocodeine
Brand name: Synalgos-DC
Synonyms: Dihydrocodeine, Aspirin, and Caffeine
Generic Name: pantoprazole
Brand name: Protonix, Protonix IV
Synonyms: Protonix
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Aspirin, caffeine, and dihydrocodeine-Protonix (Pantoprazole Delayed-Release Tablets)
- Aspirin, caffeine, and dihydrocodeine-Protonix I.V.
- Aspirin, caffeine, and dihydrocodeine-Protonix Intravenous
- Aspirin, caffeine, and dihydrocodeine-Protonix oral/injection
- Aspirin, caffeine, and dihydrocodeine-Protonix Tablets
- Aspirin, caffeine, and dihydrocodeine-Protopam
- Protonix (Pantoprazole Delayed-Release Granules)-Aspirin, caffeine, and orphenadrine
- Protonix (Pantoprazole Delayed-Release Granules)-Aspirin, carisoprodol, and codeine
- Protonix (Pantoprazole Delayed-Release Granules)-Aspirin, chlorpheniramine, and phenylephrine
- Protonix (Pantoprazole Delayed-Release Granules)-Aspirin, Citric Acid, and Sodium Bicarbonate
- Protonix (Pantoprazole Delayed-Release Granules)-Aspirin, Salicylamide, and Caffeine
- Protonix (Pantoprazole Delayed-Release Granules)-Aspirin, sodium bicarbonate, and citric acid