Aspirin, caffeine, and orphenadrine and Niacin Capsules and Tablets
Determining the interaction of Aspirin, caffeine, and orphenadrine and Niacin Capsules and Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Salicylates may cause an elevation in serum levels of nicotinic acid. The mechanism is not completely understood. However, salicylates also significantly decrease the serum levels of nicotinuric acid--a metabolite--and some experts hypothesize that salicylic acid causes a concentration-dependent decrease in the total clearance of nicotinic acid. Such a decrease would result in the saturation of the nicotinuric acid conjugation pathway. Data are available for aspirin only. No special precautions appear to be necessary.
- Ding RW, Kolbe K, Merz B, de Vries J, Weber E, Benet LZ "Pharmacokinetics of nicotinic acid-salicylic acid interaction." Clin Pharmacol Ther 46 (1989): 642-7
Generic Name: aspirin / caffeine / orphenadrine
Brand name: Norgesic Forte, Orphengesic Forte, Norgesic, Orphengesic
Synonyms: Orphenadrine Aspirin Caffeine
Generic Name: niacin
Brand name: B-3-50, B3-500-Gr, Niacin SR, Niacor, Niaspan ER, Slo-Niacin
Synonyms: Niacin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Aspirin, caffeine, and orphenadrine-Niacin Controlled-Release Capsules and Controlled-Release Tablets
- Aspirin, caffeine, and orphenadrine-Niacin SR
- Aspirin, caffeine, and orphenadrine-Niacin Tablets
- Aspirin, caffeine, and orphenadrine-Niacinamide
- Aspirin, caffeine, and orphenadrine-Niacinamide Extended-Release Tablets
- Aspirin, caffeine, and orphenadrine-Niacor
- Niacin Capsules and Tablets-Aspirin, carisoprodol, and codeine
- Niacin Capsules and Tablets-Aspirin, chlorpheniramine, and phenylephrine
- Niacin Capsules and Tablets-Aspirin, Citric Acid, and Sodium Bicarbonate
- Niacin Capsules and Tablets-Aspirin, Salicylamide, and Caffeine
- Niacin Capsules and Tablets-Aspirin, sodium bicarbonate, and citric acid
- Niacin Capsules and Tablets-Aspiritab