Aspirin Enteric-Coated and Buffered Tablets and Verapamil Injection
Determining the interaction of Aspirin Enteric-Coated and Buffered Tablets and Verapamil Injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Before using verapamil, tell your doctor if you also use aspirin. This combination may cause unusual bleeding or bruising, headache, dizziness, or weakness. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment or need your blood pressure checked more often. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Several case reports have suggested that verapamil and aspirin may have synergistic antiplatelet effects. The mechanism of this interaction has not been fully elucidated. Also, one study of five patients has suggested that aspirin may reverse the antihypertensive effect of verapamil. The mechanism may be related to antagonism of the effect of verapamil on prostacyclin. Diltiazem has been shown to interact with aspirin in a similar manner.
MANAGEMENT: Close observation for prolonged bleeding time and reduced antihypertensive effect is recommended if these drugs must be used together. Patients should be advised to notify their physician if they experience unusual bleeding, bruising, or petechiae. Aspirin should be discontinued if an interaction is suspected.
- "Product Information. Covera-HS (verapamil)." Searle, Skokie, IL.
- Das UN "Modification of anti-hypertensive action of verapamil by inhibition of endogenous prostaglandin synthesis." Prostaglandins Leukot Med 9 (1982): 167-9
- Altman R, Scazziota A, Dujovne C "Diltiazem potentiates the inhibitory effect of aspirin on platelet aggregation." Clin Pharmacol Ther 44 (1988): 320-5
- Ring ME, Corrigan JJ, Fenster PE "Effects of oral diltiazem on platelet function: alone and in combination with "low dose" aspirin." Thromb Res 44 (1986): 391-400
- Verzino E, Kaplan B, Ashley JV, Burdette M "Verapamil-aspirin interaction." Ann Pharmacother 28 (1994): 536-7
Generic Name: aspirin
Brand name: Arthritis Pain, Aspir 81, Aspir-Low, Bayer Childrens Aspirin, Durlaza, Ecotrin, Ecpirin, Fasprin, Halfprin, Miniprin, Aspiritab, Bayer, Bayer Low Strength, Bayer Children's, St. Joseph 81 mg Adult
Synonyms: Aspirin
Generic Name: verapamil
Brand name: Calan, Isoptin SR, Verelan, Isoptin, Calan SR, Isoptin IV, Covera-HS, Verelan PM
Synonyms: Verapamil
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Aspirin Enteric-Coated and Buffered Tablets-Verapamil Intravenous
- Aspirin Enteric-Coated and Buffered Tablets-Verapamil Long-Acting Capsules
- Aspirin Enteric-Coated and Buffered Tablets-Verapamil Long-Acting Tablets
- Aspirin Enteric-Coated and Buffered Tablets-Verapamil oral/injection
- Aspirin Enteric-Coated and Buffered Tablets-Verapamil Sustained-Release Capsules
- Aspirin Enteric-Coated and Buffered Tablets-Verdeso
- Verapamil Injection-Aspirin Extended-Release Capsules
- Verapamil Injection-Aspirin Low Dose Enteric Coated
- Verapamil Injection-Aspirin powder
- Verapamil Injection-Aspirin rectal
- Verapamil Injection-Aspirin Suppositories
- Verapamil Injection-Aspirin Tablets