Aspirin powder and Probenecid and colchicine
Determining the interaction of Aspirin powder and Probenecid and colchicine and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Talk to your doctor before using probenecid together with aspirin. Depending on the dose and how frequently aspirin is taken, it may interfere with the action of probenecid and reduce its effectiveness in treating gout or gouty arthritis. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Large, anti-inflammatory doses of salicylates may inhibit the uricosuric effect of probenecid. The mechanism of interaction has not been established. In contrast, low, daily antiplatelet doses do not seem to interact. In a study of 11 patients with gouty arthritis receiving a stable dosage of probenecid for at least three months, no significant effects on serum levels or 24-hour urinary excretion of uric acid were observed during coadministration with enteric-coated aspirin 325 mg/day, taken simultaneously with probenecid or 6 hours after.
MANAGEMENT: Large doses of salicylates should be avoided in patients who require probenecid for the treatment of hyperuricemia or gout. However, occasional use of low dosages for analgesia or daily use of cardioprotective dosages should generally not be a concern.
- Diamond JS, Paolino JS "Evidence for a postsecretory reabsorptive site for uric acid in man." J Clin Invest 52 (1973): 1491-9
- Regal RE "Aspirin and uricosurics: interaction revisited." Drug Intell Clin Pharm 21 (1987): 219-20
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Harris M, Bryant LR, Danaher P, Alloway J "Effect of low dose daily aspirin on serum urate levels and urinary excretion in patients receiving probenecid for gouty arthritis." J Rheumatol 27 (2000): 2873-6
Generic Name: aspirin
Brand name: Arthritis Pain, Aspir 81, Aspir-Low, Bayer Childrens Aspirin, Durlaza, Ecotrin, Ecpirin, Fasprin, Halfprin, Miniprin, Aspiritab, Bayer, Bayer Low Strength, Bayer Children's, St. Joseph 81 mg Adult
Synonyms: Aspirin
Generic Name: colchicine / probenecid
Brand name:
Synonyms: Probenecid and colchicine (Oral)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Aspirin powder-Probenecid Tablets
- Aspirin powder-Probiotic Formula (Bacillus Coagulans)
- Aspirin powder-Probucol
- Aspirin powder-Probuphine
- Aspirin powder-Procainamide
- Aspirin powder-Procainamide capsules
- Probenecid and colchicine-Aspirin rectal
- Probenecid and colchicine-Aspirin Suppositories
- Probenecid and colchicine-Aspirin Tablets
- Probenecid and colchicine-Aspirin, butalbital, and caffeine
- Probenecid and colchicine-Aspirin, butalbital, caffeine, and codeine
- Probenecid and colchicine-Aspirin, caffeine, and dihydrocodeine