Aspirin, sodium bicarbonate, and citric acid and Bupropion Hydrochloride

• Generic Name: aspirin / citric acid / sodium bicarbonate
• Dosage Forms: n.a.
• Other Brand Names: Alka-Seltzer Extra Strength, Alka-Seltzer, Medi-Seltzer, Neutralin

Aspirin, sodium bicarbonate, and citric acid combination is used to relieve pain occurring together with heartburn, sour stomach, or acid indigestion.

The aspirin in this combination is the pain reliever. Aspirin belongs to the group of medicines known as salicylates and to the group of medicines known as anti-inflammatory analgesics. The sodium bicarbonate in aspirin, sodium bicarbonate, and citric acid is an antacid. It neutralizes stomach acid by combining with it to form a new substance that is not an acid.

Aspirin, sodium bicarbonate, and citric acid combination may also be used to lessen the chance of heart attack, stroke, or other problems that may occur when a blood vessel is blocked by blood clots. The aspirin in aspirin, sodium bicarbonate, and citric acid helps prevent dangerous blood clots from forming. However, this effect of aspirin may increase the chance of serious bleeding in some people. Therefore, aspirin should be used for this purpose only when your doctor decides, after studying your medical condition and history, that the danger of blood clots is greater than the risk of bleeding. Do not take aspirin to prevent blood clots or a heart attack unless it has been ordered by your doctor.

This combination medicine is available without a prescription.

• Generic Name: bupropion
• Dosage Forms: n.a.
• Other Brand Names: Aplenzin, Buproban, Forfivo XL, Wellbutrin SR, Wellbutrin XL, Zyban, Zyban Advantage Pack, Budeprion XL

Treatment of major depressive disorder.

May be useful (alone or in combination with other antidepressants) in patients with refractory depression.

Seasonal Affective Disorder

Prevention of seasonal major depressive episodes in patients with a diagnosis of seasonal affective disorder (SAD; also referred to as winter depression).

Smoking Cessation

Adjunct in the cessation of smoking (alone or in combination with nicotine replacement therapy).

US Public Health Service (USPHS) guideline for the treatment of tobacco use and dependence recommends bupropion (as extended-release tablets) as one of several first-line drugs that may reliably increase long-term smoking abstinence rates.

Depression Associated with Bipolar Disorder

Treatment of patients with bipolar depression (bipolar disorder, depressive episode).

American Psychiatric Association (APA) considers bupropion one of several second-line agents for use when first-line agents are ineffective or not tolerated.

Attention Deficit Hyperactivity Disorder (ADHD)

Used in a limited number of children and adults in the management of ADHD.

Panic Disorder

Ineffective in the treatment of panic disorder and concomitant phobic disorder, but may improve symptoms of panic and depression in patients with major depression who have superimposed panic symptoms.

Bulimia Nervosa

Not recommended by APA for bulimia nervosa because associated with seizures in purging bulimic patients.