Aspirin, sodium bicarbonate, and citric acid and Vibramycin Calcium
Determining the interaction of Aspirin, sodium bicarbonate, and citric acid and Vibramycin Calcium and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using sodium bicarbonate together with doxycycline may decrease the effects of doxycycline. Administration of sodium bicarbonate and doxycycline should be separated by three to four hours. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSING INTERVAL: Alkalinization of the urine may decrease the plasma concentration of some tetracyclines. The mechanism is not completely understood, but may involve increased renal elimination of tetracyclines when the urine becomes alkalinized. Information is available for doxycycline, tetracycline, and sodium bicarbonate only.
MANAGEMENT: If these drugs must be used together, an alternating dosing schedule is recommended (three to four hours apart).
- Elliott GR "Sodium bicarbonate and oral tetracycline." Clin Pharmacol Ther 13 (1972): 459
- Jaffe JM, Colaizzi JI, Poust RI, McDonald RH Jr "Effect of altered urinary pH on tetracycline and doxycycline excretion in humans." J Pharmacokinet Biopharm 1 (1973): 267-82
- Jaffe JM, Poust RI, Feld SL, Colaizzi JL "Influence of repetitive dosing and altered urinary pH on doxycycline excretion in humans." J Pharm Sci 63 (1974): 1256-60
Generic Name: aspirin / citric acid / sodium bicarbonate
Brand name: Alka-Seltzer Extra Strength, Alka-Seltzer, Medi-Seltzer, Neutralin
Synonyms: Aspirin, Citric Acid, and Sodium Bicarbonate
Generic Name: doxycycline
Brand name: Vibramycin, Acticlate, Adox Pak 2/100, Adoxa, Adoxa Pak 1/100, Adoxa Pak 1/150, Avidoxy, Monodox, Morgidox, Oraxyl, TargaDOX, Adoxa CK, Adoxa Pak, Adoxa TT, Alodox, Avidoxy, Doryx, Mondoxyne NL, Oracea, Periostat Targadox, Vibramycin Calcium, Vibramycin Hyclate, Vibramycin monohydrate, Vibra-Tabs, Doxy 100, TargaDOX
Synonyms: Vibramycin (Suspension), Vibramycin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Aspirin, sodium bicarbonate, and citric acid-Vibramycin Hyclate
- Aspirin, sodium bicarbonate, and citric acid-Vicks 44 Cold, Flu and Cough
- Aspirin, sodium bicarbonate, and citric acid-Vicks 44 Cough Relief
- Aspirin, sodium bicarbonate, and citric acid-Vicks DayQuil Multi-Symptom
- Aspirin, sodium bicarbonate, and citric acid-Vicks DayQuil Multi-Symptom Cold/Flu Relief
- Aspirin, sodium bicarbonate, and citric acid-Vicks DayQuil Severe Cold/Flu
- Vibramycin Calcium-Aspiritab
- Vibramycin Calcium-Aspirtab
- Vibramycin Calcium-Astagraf XL
- Vibramycin Calcium-Astelin
- Vibramycin Calcium-Astelin Ready-Spray
- Vibramycin Calcium-Astepro