Atazanavir and cobicistat and Taztia XT

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using dilTIAZem together with atazanavir can increase your blood levels of dilTIAZem and may cause a dangerous side effect on your heart. This can cause slow heartbeat, weakness, chest pain, shortness of breath, feeling light-headed, or fainting. You may need a dose adjustment and you may need to check your blood pressure more often to safely take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSE: Coadministration with atazanavir may significantly increase the plasma concentrations of diltiazem. The mechanism is atazanavir inhibition of CYP450 3A4, the isoenzyme responsible for the metabolic clearance of diltiazem. In addition, both atazanavir and diltiazem can prolong the PR interval of the electrocardiogram and may have additive effects when used in combination. In a pharmacokinetic study, coadministration of atazanavir (400 mg once a day) and diltiazem (180 mg once a day) resulted in a 2-fold increase in diltiazem plasma concentration, and an additive effect on the PR interval was observed. Excessive prolongation of the PR interval may result in conduction disturbances and atrioventricular block.

MANAGEMENT: When used in combination with atazanavir, a reduction of diltiazem dosage by one-half should be considered and ECG monitoring is recommended. Pharmacologic response to diltiazem should be monitored more closely following addition or withdrawal of atazanavir, and the diltiazem dosage adjusted as necessary.

Atazanavir and cobicistat

Generic Name: atazanavir / cobicistat

Brand name: Evotaz

Synonyms: Atazanavir and Cobicistat

What is Atazanavir and cobicistat?

Taztia XT

Generic Name: diltiazem

Brand name: Cardizem CD, Cartia XT, Dilt-XR, Diltia XT, Taztia XT, Tiazac, Cardizem, Dilacor XR, Dilt-CD, Diltzac, Matzim LA, Tiazac, Cardizem LA, Tiazac Extended Release Capsules

Synonyms: n.a.

What is Taztia XT?