Atazanavir Capsules and Diskets

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Atazanavir does not appear to significantly affect the pharmacokinetics of methadone. In 16 HIV-negative patients on chronic methadone therapy for treatment of opiate dependency, coadministration of atazanavir (400 mg orally once daily for 14 days) reduced the steady-state peak plasma concentration (Cmax) of the pharmacologically active R(+) enantiomer of methadone by just 9% compared to administration of methadone alone. The AUC of R(+) methadone increased by 3% and the plasma trough concentration (Cmin) increased by 11% during atazanavir cotreatment. These differences were not statistically significant, and clinically relevant symptoms of opiate withdrawal or excess were not detected. For S(-) methadone, which is pharmacologically inactive, the Cmax, AUC and Cmin decreased by 21%, 15% and 10%, respectively, with atazanavir. For total (racemic) methadone, the Cmax and AUC decreased by 15% and 6%, respectively, and Cmin increased by 2% with atazanavir. Methadone also seems to have negligible effects on atazanavir pharmacokinetics, as atazanavir exposures in the study were within the range of values previously reported for healthy and HIV-infected subjects. Based on these findings, no dosage adjustments are necessary for either methadone or atazanavir during coadministration.

Atazanavir Capsules

Generic Name: atazanavir

Brand name: Reyataz

Synonyms: Atazanavir

What is Atazanavir Capsules?

Diskets

Generic Name: methadone

Brand name: Dolophine, Methadose, Methadose Sugar-Free, Diskets

Synonyms: Methadone

What is Diskets?