Atazanavir Capsules and Incivek

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Coadministration of telaprevir with atazanavir/ritonavir or atazanavir/cobicistat may decrease the plasma concentrations of telaprevir and increase the plasma concentrations of atazanavir. The proposed mechanism involves induction of telaprevir metabolism via CYP450 3A4 and, conversely, inhibition of atazanavir metabolism via the same isoenzyme. In 14 study subjects, administration of telaprevir (750 mg every 8 hours for 10 days) in combination with atazanavir/ritonavir (300 mg/100 mg once daily for 20 days) reduced the telaprevir peak plasma concentration (Cmax), systemic exposure (AUC) and trough plasma concentration (Cmin) by an average of 21%, 20% and 15%, respectively, compared to administration alone. The Cmax of atazanavir decreased by 15%, while AUC and Cmin increased by 17% and 85%, respectively, during telaprevir coadministration. The clinical significance of these changes are unknown.

Atazanavir Capsules

Generic Name: atazanavir

Brand name: Reyataz

Synonyms: Atazanavir

What is Atazanavir Capsules?

Incivek

Generic Name: telaprevir

Brand name: Incivek

Synonyms: n.a.

What is Incivek?