Atazanavir Capsules and Lamictal XR

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Atazanavir used in combination with ritonavir (Norvir) may reduce the blood levels and effects of lamoTRIgine. You may need a dose adjustment if you have been taking lamoTRIgine and are starting treatment with atazanavir and ritonavir. Your doctor may need to monitor your lamoTRIgine blood levels more frequently during this initial period, but also let your doctor know if lamoTRIgine becomes less effective or is no longer controlling your symptoms. If your doctor does increase your dosage of lamoTRIgine, be aware that it may need to be readjusted whenever treatment with atazanavir and ritonavir is stopped. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: The concomitant use of lamotrigine and atazanavir-ritonavir may reduce plasma concentrations of lamotrigine. The mechanism is induction of glucuronidation. In a study, the use of atazanavir-ritonavir (300 mg/100 mg) for 9 days decreased the plasma AUC and Cmax of a single 100 mg dose of lamotrigine by 32% and 6%, respectively.

MANAGEMENT: No dose adjustments are required when lamotrigine is added to an existing regimen of atazanavir-ritonavir. However, if the regimen includes a maintenance dose of lamotrigine and no other glucuronidation inducers, a dosage increase may be required when atazanavir-ritonavir is added to the regimen, based on clinical response and plasma levels. A dosage decrease may be required upon discontinuation of atazanavir-ritonavir. Monitoring of plasma lamotrigine levels is recommended before and after atazanavir-ritonavir is initiated or discontinued. The manufacturer's labeling should be consulted for the appropriate dosage regimen.

Atazanavir Capsules

Generic Name: atazanavir

Brand name: Reyataz

Synonyms: Atazanavir

What is Atazanavir Capsules?

Lamictal XR

Generic Name: lamotrigine

Brand name: Lamictal, Lamictal ODT, Lamictal XR, Subvenite, Lamictal, Lamictal ODT, Lamictal XR, Lamictal CD, LaMICtal Starter Kit, LaMICtal ODT Patient Titration Kit, LaMICtal XR Patient Titration Kit, LamoTRIgine Starter Kit, Subvenite Starter Kit

Synonyms: n.a.

What is Lamictal XR?