Atazanavir Powder for Oral Suspension and Kaletra

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using atazanavir together with ritonavir may increase the effects of atazanavir. Contact your doctor if you experience increased urination or extreme thirst, severe pain in your side or lower back, painful urination, blood in your urine, easy bruising or bleeding, signs of a new infection, such as fever or chills, cough, or flu symptoms, or jaundice (yellowing of the skin or eyes). If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSE: Coadministration with ritonavir may significantly increase the plasma concentrations of atazanavir. The mechanism is ritonavir inhibition of CYP450 3A4, the isoenzyme responsible for the metabolic clearance of atazanavir. In 28 study subjects, ritonavir (100 mg once a day for 10 days) increased the mean steady-state peak plasma concentration (Cmax), area under the concentration-time curve (AUC) and trough plasma concentration (Cmin) of atazanavir (300 mg once a day) by 86%, 238% and over 1000%, respectively, compared to administration of atazanavir alone. Compared with historical data from standard therapeutic dosing of atazanavir alone at 400 mg once a day, administration of atazanavir/ritonavir at 300 mg/100 mg once a day increased atazanavir mean Cmax, AUC and Cmin by 18%, 103% and 671%, respectively.

MANAGEMENT: Patients requiring the combination should be prescribed atazanavir 300 mg with ritonavir 100 mg as a single daily dose with food.

Atazanavir Powder for Oral Suspension

Generic Name: atazanavir

Brand name: Reyataz

Synonyms: Atazanavir

What is Atazanavir Powder for Oral Suspension?

Kaletra

Generic Name: lopinavir / ritonavir

Brand name: Kaletra

Synonyms: n.a.

What is Kaletra?