Atazanavir Powder for Oral Suspension and Ketoconazole (Systemic)

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Ketoconazole may increase the blood levels and effects of atazanavir. This may increase the risk and/or severity of side effects such as jaundice, kidney stones, gallstones, high blood sugar, diabetes, and irregular heartbeat. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if you develop yellowing of the skin or eyes, pain in your side or lower back, painful urination, blood in your urine, abdominal pain or tenderness, or sudden dizziness, lightheadedness, fainting, or a slow heart rate during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of atazanavir, which is primarily metabolized by the isoenzyme.

MANAGEMENT: Caution is advised if atazanavir is used with CYP450 3A4 inhibitors, particularly potent ones like other protease inhibitors, macrolide antibiotics, itraconazole, ketoconazole, and nefazodone. Pharmacologic response to atazanavir should be monitored more closely whenever a CYP450 3A4 inhibitor is added to or withdrawn from therapy. In addition, many CYP450 3A4 inhibitors are also substrates of the isoenzyme, thus pharmacologic response to these agents should also be monitored during coadministration with atazanavir.

Atazanavir Powder for Oral Suspension

Generic Name: atazanavir

Brand name: Reyataz

Synonyms: Atazanavir

What is Atazanavir Powder for Oral Suspension?

Ketoconazole (Systemic)

Generic Name: ketoconazole

Brand name: Nizoral

Synonyms: Ketoconazole

What is Ketoconazole (Systemic)?