Atazanavir Powder for Oral Suspension and Voriconazole Oral, Intravenous
Determining the interaction of Atazanavir Powder for Oral Suspension and Voriconazole Oral, Intravenous and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using atazanavir together with voriconazole can increase the blood levels or add to the side effects of either medication. Contact your doctor if you experience increased side effects or your condition changes. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Based on in vitro data, coadministration of voriconazole with a protease inhibitor may result in increased plasma concentrations of one or both drugs. The proposed mechanism is competitive inhibition of the CYP450 3A4 isoenzyme, of which voriconazole and protease inhibitors are known substrates as well as inhibitors. However, coadministration of indinavir (800 mg three times a day for 10 days) reportedly had no significant effect on the steady-state peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of voriconazole (200 mg every 12 hours for 17 days) in healthy subjects. Voriconazole also did not significantly affect indinavir Cmax and AUC during coadministration for 7 days in healthy volunteers.
MANAGEMENT: Caution is advised if voriconazole must be used concomitantly with protease inhibitors. Patients should be frequently monitored for drug toxicity during coadministration of these drugs, and the dosage(s) adjusted accordingly.
- "Product Information. VFEND (voriconazole)." Pfizer U.S. Pharmaceuticals, New York, NY.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Generic Name: atazanavir
Brand name: Reyataz
Synonyms: Atazanavir
Generic Name: voriconazole
Brand name: Vfend, Vfend
Synonyms: Voriconazole (oral/injection), Voriconazole
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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