Atazanavir Powder for Oral Suspension and Vosevi

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Atazanavir may significantly increase the blood levels of voxilaprevir, the safety of which has not been established. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration with atazanavir/ritonavir or lopinavir/ritonavir may significantly increase the plasma concentrations of voxilaprevir. The proposed mechanism is inhibition of organic anion transporting polypeptide (OATP) 1B1-mediated hepatic uptake of voxilaprevir by atazanavir, lopinavir, and ritonavir. Inhibition of P-glycoprotein-mediated intestinal efflux and CYP450 3A4-mediated metabolism of voxilaprevir may also contribute. When a single 400 mg/100 mg/100 mg dose of sofosbuvir/velpatasvir/voxilaprevir was administered with a single 300 mg dose of atazanavir plus 100 mg dose of ritonavir to 15 healthy study subjects, mean voxilaprevir peak plasma concentration (Cmax) and systemic exposure (AUC) increased by approximately 4.4- and 4.3-fold, respectively. Mean velpatasvir Cmax and AUC were also increased by approximately 1.3- and 1.9-fold, respectively, while mean sofosbuvir Cmax and AUC were increased by 1.3- and 1.4-fold, respectively. No data are available for sofosbuvir/velpatasvir/voxilaprevir administered with lopinavir/ritonavir, but a similar interaction should be expected.

MANAGEMENT: Concomitant use of sofosbuvir/velpatasvir/voxilaprevir with atazanavir- or lopinavir-containing regimens is not recommended.

Atazanavir Powder for Oral Suspension

Generic Name: atazanavir

Brand name: Reyataz

Synonyms: Atazanavir

What is Atazanavir Powder for Oral Suspension?

Vosevi

Generic Name: sofosbuvir / velpatasvir / voxilaprevir

Brand name: Vosevi

Synonyms: n.a.

What is Vosevi?