Atazanavir Sulfate and Lidocaine Oropharyngeal Solution
Determining the interaction of Atazanavir Sulfate and Lidocaine Oropharyngeal Solution and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using lidocaine together with atazanavir can increase the effects of lidocaine and may affect the rhythm of your heart. Call your doctor if you have symptoms of irregular heartbeat, chest tightness, blurred vision or nausea. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with atazanavir may increase the plasma concentrations of amiodarone, systemic lidocaine, and quinidine. The proposed mechanism is atazanavir inhibition of CYP450 3A4, the isoenzyme responsible for the metabolic clearance of these antiarrhythmic agents. The interaction has not been studied but could conceivably lead to serious and/or life-threatening reactions including cardiac arrhythmias and other toxicities.
MANAGEMENT: Caution is advised if atazanavir must be used with amiodarone, systemic lidocaine, or quinidine. Pharmacologic response and plasma antiarrhythmic drug levels should be monitored more closely whenever atazanavir is added to or withdrawn from therapy, and the antiarrhythmic dosage adjusted as necessary. According to some authorities, use of the fixed combination atazanavir-cobicistat with these antiarrhythmic agents is considered contraindicated.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- "Product Information. Reyataz (atazanavir)." Bristol-Myers Squibb, Princeton, NJ.
Generic Name: atazanavir
Brand name: Reyataz
Synonyms: Atazanavir
Generic Name: lidocaine
Brand name: UAD Caine, Xylocaine HCl, Xylocaine-MPF, Lidoject 1, Xylocaine Dental Cartridges, Lidoject 2, Xylocaine Duo-Trach Kit, Xylocaine HCl For Spinal, L-Caine, Dilocaine, Nervocaine, Truxacaine, Anestacaine
Synonyms: Lidocaine injection, Lidocaine (Systemic)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Atazanavir Sulfate-Lidocaine Patch
- Atazanavir Sulfate-Lidocaine Rectal Cream
- Atazanavir Sulfate-Lidocaine Rectal Cream and Gel
- Atazanavir Sulfate-Lidocaine Skin Liquid
- Atazanavir Sulfate-Lidocaine Spray
- Atazanavir Sulfate-Lidocaine topical
- Lidocaine Oropharyngeal Solution-Atelvia
- Lidocaine Oropharyngeal Solution-Atendia Patch
- Lidocaine Oropharyngeal Solution-Atenolol
- Lidocaine Oropharyngeal Solution-Atenolol and chlorthalidone
- Lidocaine Oropharyngeal Solution-Atenolol and Chlorthalidone Tablets
- Lidocaine Oropharyngeal Solution-Atenolol Intravenous