Atezolizumab Intravenous and Disopyramide Phosphate

• Generic Name: atezolizumab
• Dosage Forms: n.a.
• Other Brand Names: Tecentriq

Atezolizumab injection is used to treat urothelial carcinoma (a type of bladder cancer) that has spread throughout the body (metastatic) or cannot be removed by surgery (advanced). Atezolizumab is given to patients who have received other cancer medicines (eg, platinum) that did not work well or given to patients who cannot receive cancer medicines containing cisplatin.

Atezolizumab injection is also used to treat metastatic non-small cell lung cancer in patients who have received cancer medicines containing platinum that did not work well.

Atezolizumab is to be given only by or under the supervision of your doctor.

• Generic Name: disopyramide
• Dosage Forms: n.a.
• Other Brand Names: Norpace, Norpace CR

Precise role in antiarrhythmic therapy has not been established. Some experts recommend that disopyramide be reserved for use as an alternative drug when lidocaine, quinidine, or procainamide is ineffective or adverse effects of these drugs are intolerable.

Limited information is available on combination therapy with other antiarrhythmic drugs such as lidocaine, quinidine, or procainamide to treat or prevent serious, refractory arrhythmias.

Suppression and prevention of recurrent life-threatening ventricular arrhythmias (e.g., sustained VT). (See Boxed Warning.)

Because of disopyramide’s arrhythmogenic potential and lack of evidence for improved survival for class I antiarrhythmic agents, use for less severe arrhythmias is not recommended.

Avoid treatment of asymptomatic VPCs.

Has been used to convert atrial fibrillation, atrial flutter, and paroxysmal atrial tachycardia to normal sinus rhythm. However, other antiarrhythmic drugs (e.g., dofetilide, flecainide, ibutilide, propafenone, amiodarone) are preferred.