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Ativan and Evening Primrose Oil

Determining the interaction of Ativan and Evening Primrose Oil and the possibility of their joint administration.

Check result:

Ativan <> Evening Primrose Oil

Relevance: 27.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Some clinicians have suggested that evening primrose and borage oil, both of which contain the omega-6 fatty acid gamma linolenic acid, may lower the seizure threshold and antagonize the effects of anticonvulsants. However, data regarding the effect of gamma linolenic acid on seizure threshold are conflicting and limited. The possibility of an interaction should be considered if loss of seizure control occurs in patients taking evening primrose or borage oil.

References

Asadi-Samani M, Bahmani M, Rafieian-Kopaei M "The chemical composition, botanical characteristic and biological activities of Borago officinalis: a review." Asian Pac J Trop Med 7S1 (2014): S22-8
Miller LG "Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions." Arch Intern Med 158 (1998): 2200-11
Therapeutic Research Faculty "Natural Medicines Comprehensive Database. Available from: URL: http://www.naturaldatabase.com." ([1995-2008...]):
N. A. Michael Eskin "Borage and evening primrose oil." European Journal of Lipid Science and Technology 110 (2008): 1

Ativan

Generic Name: lorazepam

Brand name: Ativan, Lorazepam Intensol

Synonyms: n.a.

What is Ativan?

Evening Primrose Oil

Generic Name: evening primrose

Brand name: Primrose Oil, Evening Primrose Oil

Synonyms: Evening Primrose

What is Evening Primrose Oil?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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