Drug search by name

Ativan and Lopressor Injection

Determining the interaction of Ativan and Lopressor Injection and the possibility of their joint administration.

Check result:

Ativan <> Lopressor Injection

Relevance: 27.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

The pharmacologic effects of some benzodiazepines may be increased by some beta-blockers. Propranolol and metoprolol may inhibit the hepatic metabolism of diazepam and other mechanisms may also be involved. Most changes have been clinically insignificant; however, increased reaction times and/or decreased kinetic visual acuity have been reported with some combinations. Observation for altered benzodiazepine effects is recommended if these drugs must be used together. Patients should be warned against driving or operating hazardous machinery.

References

Ochs HR, Greenblatt DJ, Locniskar A, Weinbrenner J "Influence of propranolol coadministration or cigarette smoking on the kinetics of desmethyldiazepam following intravenous clorazepate." Klin Wochenschr 64 (1986): 1217-21
Sonne J, Dossing M, Loft S, et al "Single dose pharmacokinetics and pharmacodynamics of oral oxazepam during concomitant administration of propranolol and labetalol." Br J Clin Pharmacol 29 (1990): 33-7
Hawksworth G, Betts T, Crowe A, et al "Diazepam/beta-adrenoceptor antagonist interactions." Br J Clin Pharmacol 17 Suppl 1 (1984): s69-76
Klotz U, Reimann IW "Pharmacokinetic and pharmacodynamic interaction study of diazepam and metoprolol." Eur J Clin Pharmacol 26 (1984): 223-6
Ochs HR, Greenblatt DJ, Verburg-Ochs B "Propranolol interactions with diazepam, lorazepam and alprazolam." Clin Pharmacol Ther 36 (1984): 451-5
Scott AK, Cameron GA, Hawksworth GM "Interaction of metoprolol with lorazepam and bromazepam." Eur J Clin Pharmacol 40 (1991): 405-9

Ativan

Generic Name: lorazepam

Brand name: Ativan, Lorazepam Intensol

Synonyms: n.a.

What is Ativan?

Lopressor Injection

Generic Name: metoprolol

Brand name: Lopressor, Kapspargo Sprinkle, Toprol-XL, Toprol XL

Synonyms: Lopressor (Injection), Lopressor

What is Lopressor Injection?

+ Add a drug Remove all

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions