ATNAA and Ethacrynate Sodium

• Generic Name: atropine / pralidoxime
• Dosage Forms: injection
• Other Brand Names: ATNAA, DuoDote

Atropine blocks the action of a certain chemical that may reach high levels in the body after a poisoning. Atropine also stimulates the heart and reduces the secretions of the nose, mouth, and lungs to improve breathing.

Pralidoxime reverses muscle weakness or paralysis caused by a poison or nerve agent.

ATNAA is a combination medicine used as an antidote to treat poisoning by a pesticide (insect spray) or a chemical that interferes with the central nervous system, such as nerve gas.

ATNAA is not effective as an antidote for all types of pesticide poisonings. You may need medications or additional treatments.

ATNAA may also be used for purposes not listed in this medication guide.

• Generic Name: ethacrynic acid
• Dosage Forms: n.a.
• Other Brand Names: Edecrin, Edecrin Sodium, Sodium Edecrin

Management of edema associated with heart failure, hepatic cirrhosis, and renal disease (e.g., nephrotic syndrome).

Considered a diuretic of choice for most patients with heart failure.

Most experts state that all patients with symptomatic heart failure who have evidence for, or a history of, fluid retention generally should receive diuretic therapy in conjunction with moderate sodium restriction, an agent to inhibit the renin-angiotensin-aldosterone (RAA) system (e.g., ACE inhibitor, angiotensin II receptor antagonist, angiotensin receptor-neprilysin inhibitor [ARNI]), a β-adrenergic blocking agent (β-blocker), and in selected patients, an aldosterone antagonist.

Short-term management of ascites associated with malignancy, idiopathic edema, or lymphedema.

Short-term management of hospitalized pediatric patients, other than infants, with congenital heart disease or nephrotic syndrome. (See Pediatric Use under Cautions.)

IV ethacrynate sodium is used when rapid onset of diuresis is needed (e.g., acute pulmonary edema).

Has been used in the management of hypertension. However, not a recommended agent in current hypertension management guidelines.

May still be considered when diuretic therapy is indicated in patients hypersensitive to sulfonamides (e.g., other loop diuretics, thiazides) because ethacrynic acid is not a sulfonamide.

IV ethacrynate sodium has been used as an adjunct to hypotensive agents in the management of hypertensive crisis, especially when accompanied by pulmonary edema.

IV ethacrynate sodium has been used in the management of hypercalcemia, alone or with sodium chloride 0.9% injection.

Has been used with mannitol in the management of ethylene glycol poisoning.

Management of bromide intoxication.

Treatment of nephrogenic diabetes insipidus that is refractory to vasopressin or chlorpropamide.