Atorvastatin and Hydrochlorothiazide and aliskiren
Determining the interaction of Atorvastatin and Hydrochlorothiazide and aliskiren and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using atorvastatin together with aliskiren can increase the effects of aliskiren. You should be advised to contact your doctor if you experience excessive side effects of aliskiren such as dizziness, lightheadedness, diarrhea, abdominal pain, and gastroesophageal reflux. You may need a dose adjustment or special tests if your use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with atorvastatin may increase the plasma concentrations of aliskiren. The exact mechanism of interaction is unknown but may involve competitive inhibition of the CYP450 3A4 metabolism of aliskiren. According to the product labeling, peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of aliskiren were increased approximately 50% by atorvastatin following multiple dosing. Aliskiren had no significant effect on the pharmacokinetics of atorvastatin.
MANAGEMENT: Caution is advised during coadministration of aliskiren with atorvastatin. Antihypertensive response should be monitored more closely following initiation, discontinuation, or change of dosage of atorvastatin in patients who are stabilized on their aliskiren regimen. Patients should be advised to notify their physician if they experience excessive adverse effects of aliskiren such as dizziness, lightheadedness, diarrhea, abdominal pain, and gastroesophageal reflux.
- "Product Information. Tekturna (aliskiren)." Novartis Pharmaceuticals, East Hanover, NJ.
Generic Name: atorvastatin
Brand name: Lipitor
Synonyms: AtorvaSTATin
Generic Name: aliskiren / hydrochlorothiazide
Brand name: Tekturna HCT
Synonyms: Aliskiren and Hydrochlorothiazide
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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- Atorvastatin-Hydrochlorothiazide and captopril
- Atorvastatin-Hydrochlorothiazide and enalapril
- Hydrochlorothiazide and aliskiren-Atorvastatin and ezetimibe
- Hydrochlorothiazide and aliskiren-Atorvastatin Calcium
- Hydrochlorothiazide and aliskiren-Atovaquone
- Hydrochlorothiazide and aliskiren-Atovaquone and proguanil
- Hydrochlorothiazide and aliskiren-Atovaquone and Proguanil Hydrochloride
- Hydrochlorothiazide and aliskiren-Atovaquone Suspension