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Atorvastatin and ezetimibe and Colestipol

Determining the interaction of Atorvastatin and ezetimibe and Colestipol and the possibility of their joint administration.

Check result:

Atorvastatin and ezetimibe <> Colestipol

Relevance: 11.05.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using colestipol together with ezetimibe may decrease the effects of ezetimibe. Ezetimibe should be administered at least 2 hours before or 4 hours after colestipol. Contact your doctor if your condition worsens. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSING INTERVAL: In a study of 40 healthy hypercholesterolemic adults, concomitant administration of cholestyramine (4 g twice daily) decreased the mean area under the plasma concentration-time curve (AUC) of total ezetimibe by approximately 55%. The incremental LDL cholesterol reduction expected with the addition of ezetimibe to cholestyramine or other bile acid sequestrants may be diminished by this interaction.

MANAGEMENT: Ezetimibe should be administered at least 2 hours before or 4 hours after the bile acid sequestrant.

References

"Product Information. Zetia (ezetimibe)." Schering-Plough Corporation, Kenilworth, NJ.

Atorvastatin and ezetimibe

Generic Name: atorvastatin / ezetimibe

Brand name: Liptruzet

Synonyms: Atorvastatin and ezetimibe (Oral)

What is Atorvastatin and ezetimibe?

Colestipol

Generic Name: colestipol

Brand name: Colestid, Colestid Flavored

Synonyms: n.a.

What is Colestipol?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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