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Atovaquone and proguanil and Pms-Etoposide

Determining the interaction of Atovaquone and proguanil and Pms-Etoposide and the possibility of their joint administration.

Check result:
Atovaquone and proguanil <> Pms-Etoposide
Relevance: 28.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using atovaquone together with etoposide may increase the effects of atovaquone. Contact your doctor if you experience severe nausea and vomiting, fever, chills, sore throat, flu symptoms, easy bruising, or extreme weakness. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: The coadministration with atovaquone may modestly increase the plasma concentrations of etoposide and its catechol metabolite. The mechanism of interaction is unknown. In nine children treated with etoposide (300 mg/m2 intravenous infusion), atovaquone (45 mg/kg/day in 2 divided doses) increased the area under the plasma concentration-time curve (AUC) of etoposide and its catechol metabolite by a median of 8.6% and 28.4%, respectively, compared to administration following daily sulfamethoxazole-trimethoprim.

MANAGEMENT: Given the risk of etoposide-related secondary acute myeloid leukemia associated with minor changes in schedule and concurrent therapy, caution is advised during the simultaneous administration of atovaquone and etoposide. Patients should be monitored for etoposide toxicity such as myelosuppression.

References
  • van de Poll ME, Relling MV, Schuetz EG, Harrison PL, Hughes W, Flynn PM "The effect of atovaquone on etoposide pharmacokinetics in children with acute lymphoblastic leukemia." Cancer Chemother Pharmacol 47 (2001): 467-72
Atovaquone and proguanil

Generic Name: atovaquone / proguanil

Brand name: Malarone, Malarone Pediatric

Synonyms: Atovaquone and Proguanil

Pms-Etoposide

Generic Name: etoposide

Brand name: VePesid, Etopophos, Toposar

Synonyms: Etoposide

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle