Atovaquone and proguanil and Zidovudine Capsules and Tablets

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Coadministration with atovaquone has been shown to increase the plasma concentrations of zidovudine. The mechanism appears to be inhibition of zidovudine glucuronidation by atovaquone. In 14 HIV-infected volunteers, administration of zidovudine (200 mg every 8 hours) with atovaquone tablets (750 mg every 12 hours) resulted in a 24% decrease in zidovudine apparent oral clearance and a 35% increase in plasma zidovudine area under the concentration-time curve (AUC) compared to administration without atovaquone. Additionally, the formation of the zidovudine glucuronide metabolite was reduced in the presence of atovaquone. These changes are unlikely to be of clinical significance, although the magnitude of interaction may be increased with atovaquone suspension due to its greater bioavailability over the tablets. Zidovudine had no effect on the pharmacokinetics of atovaquone.

Atovaquone and proguanil

Generic Name: atovaquone / proguanil

Brand name: Malarone, Malarone Pediatric

Synonyms: Atovaquone and Proguanil

What is Atovaquone and proguanil?

Zidovudine Capsules and Tablets

Generic Name: zidovudine

Brand name: Retrovir

Synonyms: Zidovudine (oral/injection), Zidovudine

What is Zidovudine Capsules and Tablets?