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Atovaquone and Proguanil Hydrochloride and Jantoven

Determining the interaction of Atovaquone and Proguanil Hydrochloride and Jantoven and the possibility of their joint administration.

Check result:

Atovaquone and Proguanil Hydrochloride <> Jantoven

Relevance: 12.12.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using warfarin together with proguanil can cause you to bleed more easily. Call your doctor promptly if you have any unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Proguanil may potentiate the hypoprothrombinemic effect of warfarin and similar anticoagulants through possible interference with metabolic pathways. In one case report, a woman stabilized on warfarin developed hematuria, bruising, and abdominal pain in association with a prothrombin ratio of 8.6 after approximately 5 weeks of proguanil coadministration. The patient was successfully treated with fresh frozen plasma and vitamin K.

MANAGEMENT: Given the potential for interaction and the high degree of interpatient variability with respect to warfarin metabolism, patients should be closely monitored during concomitant therapy with proguanil. The INR should be checked frequently and warfarin dosage adjusted accordingly, particularly following initiation or discontinuation of proguanil therapy in patients who are stabilized on their warfarin regimen. The same precaution may be applicable during therapy with other oral anticoagulants, although clinical data are lacking. Patients should be advised to promptly report any signs of bleeding to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools.

References

"Product Information. Malarone (atovaquone-proguanil)" Glaxo Wellcome, Research Triangle Pk, NC.
"Warfarin potentiated by proguanil." BMJ 303 (1991): 789

Atovaquone and Proguanil Hydrochloride

Generic Name: atovaquone / proguanil

Brand name: Malarone, Malarone Pediatric

Synonyms: Atovaquone and proguanil, Atovaquone and Proguanil

What is Atovaquone and Proguanil Hydrochloride?

Jantoven

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: n.a.

What is Jantoven?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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