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Atovaquone and Proguanil Hydrochloride and Rifadin IV

Determining the interaction of Atovaquone and Proguanil Hydrochloride and Rifadin IV and the possibility of their joint administration.

Check result:

Atovaquone and Proguanil Hydrochloride <> Rifadin IV

Relevance: 12.12.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using atovaquone together with rifAMPin. Using these medications together can make atovaquone less effective. Contact your doctor immediately if your infection or condition worsens. You may need a dose adjustment if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Coadministration with a rifamycin may decrease the plasma concentrations of atovaquone. The exact mechanism is unknown but may be related to the enzyme-inducing effects of rifamycins. In 13 HIV-infected volunteers, administration of atovaquone suspension (750 mg orally every 12 hours) with rifampin (600 mg orally every 24 hours) resulted in a 52% decrease in the average steady-state plasma atovaquone concentration and a 39% reduction in atovaquone half-life (from 82 hours to 50 hours) compared to administration without rifampin. Similarly, concomitant administration of rifabutin has been shown to reduce atovaquone plasma concentrations by approximately 34%.

MANAGEMENT: The use of atovaquone in combination with rifampin or rifabutin is not recommended. The same precaution may be applicable to rifapentine, although clinical data are lacking.

References

Goodwin SD, Fish DN "Criteria for use of atovaquone oral suspension in adult inpatients and outpatients." Am J Health Syst Pharm 52 (1995): 2460-2
"Product Information. Malarone (atovaquone-proguanil)" Glaxo Wellcome, Research Triangle Pk, NC.
"Product Information. Mepron (atovaquone)." Glaxo Wellcome, Research Triangle Park, NC.

Atovaquone and Proguanil Hydrochloride

Generic Name: atovaquone / proguanil

Brand name: Malarone, Malarone Pediatric

Synonyms: Atovaquone and proguanil, Atovaquone and Proguanil

What is Atovaquone and Proguanil Hydrochloride?

Rifadin IV

Generic Name: rifampin

Brand name: Rifadin IV, Rifadin, Rimactane

Synonyms: n.a.

What is Rifadin IV?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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