Atracurium and Verapamil Hydrochloride PM
Determining the interaction of Atracurium and Verapamil Hydrochloride PM and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using atracurium together with verapamil can prolong the effects of atracurium. You should be closely monitored for prolong breathing cessation and respiratory paralysis after use of verapamil. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Some calcium channel blockers may enhance the neuromuscular blocking properties of nondepolarizing muscle relaxants. The mechanism is not known, but may involve blockage of calcium channels on skeletal muscle. Data are available for verapamil, diltiazem, nicardipine, atracurium, vecuronium, and pancuronium.
MANAGEMENT: Patients should be closely monitored for prolonged neuromuscular blockade. Reduced doses of muscle relaxants may be necessary. Profound neuromuscular blockade may be reversed by neostigmine or edrophonium.
- Saitoh Y, Makita K, Tanaka H "Diltiazem and vecuronium: neuromuscular and cardiovascular effects." Can J Anaesth 44 (1997): 99
- Wali FA "Interaction of verapamil with d-tubocurarine and cholinergic agonists at the avian neuromuscular junction." Acta Anaesthesiol Scand 31 (1987): 15-20
- Carlos R, Erill S "Therapeutic Rounds." Clin Ther 9 (1986): 22-3
- Sekerci S, Tulunay M "Interactions of calcium channel blockers with non-depolarising muscle relaxants in vitro." Anaesthesia 51 (1996): 140-4
Generic Name: verapamil
Brand name: Calan, Isoptin SR, Verelan, Isoptin, Calan SR, Isoptin IV, Covera-HS, Verelan PM
Synonyms: Verapamil
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Atracurium-Verapamil Immediate-Release Tablets
- Atracurium-Verapamil Injection
- Atracurium-Verapamil Intravenous
- Atracurium-Verapamil Long-Acting Capsules
- Atracurium-Verapamil Long-Acting Tablets
- Atracurium-Verapamil oral/injection
- Verapamil Hydrochloride PM-Atracurium Besylate
- Verapamil Hydrochloride PM-Atracurium Besylate Injection
- Verapamil Hydrochloride PM-Atralin
- Verapamil Hydrochloride PM-Atralin Gel
- Verapamil Hydrochloride PM-Atralin Topical
- Verapamil Hydrochloride PM-Atridox