Atracurium Besylate and Bevacizumab Intravenous

• Generic Name: atracurium
• Dosage Forms: n.a.
• Other Brand Names:

Production of skeletal muscle relaxation during surgery after general anesthesia has been induced.

Facilitation of endotracheal intubation; however, a neuromuscular blocking agent with a rapid onset of action (e.g., succinylcholine, rocuronium) generally preferred in emergency situations when rapid intubation is required.

Also has been used to facilitate mechanical ventilation in the ICU. Has been given as a continuous IV infusion for up to 10 days in this setting. Whenever neuromuscular blocking agents are used in the ICU, consider benefits versus risks of such therapy and assess patients frequently to determine need for continued paralysis. (See Intensive Care Setting under Cautions.)

Compared with other neuromuscular blocking agents, atracurium has an intermediate onset and duration of action; exhibits minimal cardiovascular effects; and has minimal, if any, cumulative effects. Because elimination is not dependent on renal or hepatic pathways, may be particularly useful in patients with hepatic or renal dysfunction.

• Generic Name: bevacizumab
• Dosage Forms: n.a.
• Other Brand Names: Avastin, Mvasi

Bevacizumab injection is given with other medicines to treat patients with metastatic (cancer that has spread) carcinoma of the colon or rectum. Bevacizumab is also used to treat a certain type of metastatic lung cancer called nonsquamous, non-small cell lung cancer, and a certain type of brain tumor called glioblastoma that keeps coming back (recurrent).

Bevacizumab injection is also used in combination with other medicines (eg, interferon alfa) to treat patients with metastatic kidney cancer. It is also used in combination with other medicines (eg, paclitaxel and cisplatin, or paclitaxel and topotecan) to treat patients with cervical cancer that is continuing, keeps coming back, or has spread to other parts of the body. Bevacizumab is also used in combination with other medicines (eg, paclitaxel, pegylated liposomal doxorubicin, topotecan, carboplatin and paclitaxel, or carboplatin and gemcitabine followed by Avastin® alone) to treat patients with platinum-resistant, recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer with or without having previous surgery.

Bevacizumab is a substance that helps the body fight cancer. It prevents the growth of certain types of blood vessels to cancer cells. This helps to decrease the growth of cancer cells by starving the cells of nutrients that are needed to grow.

Bevacizumab is to be given only by or under the immediate supervision of your doctor.