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Atracurium Besylate and Carbastat

Determining the interaction of Atracurium Besylate and Carbastat and the possibility of their joint administration.

Check result:
Atracurium Besylate <> Carbastat
Relevance: 16.04.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using atracurium together with carbachol ophthalmic can interfere with the effects of atracurium. You should be closely monitored for adequate treatment results with atracurium. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Carbachol antagonizes the action of nondepolarizing neuromuscular blocking agents due to antagonistic effects at the neuromuscular junction in skeletal muscle.

MANAGEMENT: The patient should be monitored for adequate neuromuscular blockade and the dosage adjusted, if necessary.

References
  • Benjamin KW "Toxicity of ocular medications." Int Ophthalmol Clin 19 (1979): 199-255
  • Hardman JG, Limbird LE, Gilman AG, eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 10th ed." New York, NY: McGraw-Hill (2001):
Atracurium Besylate

Generic Name: atracurium

Brand name:

Synonyms: Atracurium

Carbastat

Generic Name: carbachol ophthalmic

Brand name: Isopto Carbachol, Miostat, Carboptic, Carbastat

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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