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Atracurium Besylate and Dilantin Infatabs

Determining the interaction of Atracurium Besylate and Dilantin Infatabs and the possibility of their joint administration.

Check result:

Atracurium Besylate <> Dilantin Infatabs

Relevance: 16.04.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using phenytoin together with atracurium may alter the effects of atracurium and cause your condition to change. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Case reports have suggested that long-term phenytoin administration may decrease the effectiveness of neuromuscular blocker and increase the dosage requirements. One of the proposed mechanisms is hepatic enzyme induction by phenytoin. Conversely, acute phenytoin administration may increase neuromuscular blocking effects by an unknown mechanism. Other hydantoins may interact with other non-depolarizing neuromuscular blockers in a similar fashion.

MANAGEMENT: Close observation for evidence of altered effects of neuromuscular blocking agents is indicated if these drugs must be used together.

References

Liberman BA, Norman P, Hardy BG "Pancuronium-phenytoin interaction: a case of decreased duration of neuromuscular blockade." Int J Clin Pharmacol Ther Toxicol 26 (1988): 371-4
Plotkin CN, Ornstein E "Resistance to pancuronium: adult respiratory distress syndrome or phenytoin." Anesth Analg 65 (1986): 819-27

Atracurium Besylate

Generic Name: atracurium

Brand name:

Synonyms: Atracurium

What is Atracurium Besylate?

Dilantin Infatabs

Generic Name: phenytoin

Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt

Synonyms: Dilantin

What is Dilantin Infatabs?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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