Atracurium Besylate and Vecuronium Bromide

• Generic Name: atracurium
• Dosage Forms: n.a.
• Other Brand Names:

Production of skeletal muscle relaxation during surgery after general anesthesia has been induced.

Facilitation of endotracheal intubation; however, a neuromuscular blocking agent with a rapid onset of action (e.g., succinylcholine, rocuronium) generally preferred in emergency situations when rapid intubation is required.

Also has been used to facilitate mechanical ventilation in the ICU. Has been given as a continuous IV infusion for up to 10 days in this setting. Whenever neuromuscular blocking agents are used in the ICU, consider benefits versus risks of such therapy and assess patients frequently to determine need for continued paralysis. (See Intensive Care Setting under Cautions.)

Compared with other neuromuscular blocking agents, atracurium has an intermediate onset and duration of action; exhibits minimal cardiovascular effects; and has minimal, if any, cumulative effects. Because elimination is not dependent on renal or hepatic pathways, may be particularly useful in patients with hepatic or renal dysfunction.

• Generic Name: vecuronium
• Dosage Forms: n.a.
• Other Brand Names: Vecuronium Bromide, Norcuron

Vecuronium Bromide is used to relax the muscles. It works by blocking the signals between your nerves and your muscles.

Vecuronium Bromide is given before general anesthesia in preparing you for surgery. Vecuronium Bromide helps to keep your body still during surgery. It also relaxes your throat so a breathing tube can be more easily inserted before the surgery.

Vecuronium Bromide may also be used for purposes not listed in this medication guide.