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Atracurium Besylate Injection and Axid Oral Solution

Determining the interaction of Atracurium Besylate Injection and Axid Oral Solution and the possibility of their joint administration.

Check result:

Atracurium Besylate Injection <> Axid Oral Solution

Relevance: 16.12.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Ranitidine may or may not decrease the effectiveness of neuromuscular blocking agents. The mechanism is unknown. Data have been conflicting and causality has not been clearly determined due to the presence of other drugs. Until more information is available, the clinician should be aware of the possibility of an interaction.

References

McCarthy G, Mirakhur RK, Elliott P, Wright J "Effect of H2-receptor antagonist pretreatment on vecuronium- and atracurium-induced neuromuscular block." Br J Anaesth 66 (1991): 713-5
Katende RS, Dimich I "Resistance to nondepolarizing muscle relaxants in a patient treated with ranitidine." Mt Sinai J Med 54 (1987): 330-1
Woodworth GE, Sears DH, Grove TM, et al "The effect of cimetidine and ranitidine on the duration of action of succinylcholine." Anesth Analg 68 (1989): 295-7

Atracurium Besylate Injection

Generic Name: atracurium

Brand name:

Synonyms: Atracurium

What is Atracurium Besylate Injection?

Axid Oral Solution

Generic Name: nizatidine

Brand name: Baciguent, Probiotic Formula, Proferrin-ES

Synonyms: n.a.

What is Axid Oral Solution?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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