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Atropine injection and Ketoconazole Tablets

Determining the interaction of Atropine injection and Ketoconazole Tablets and the possibility of their joint administration.

Check result:

Atropine injection <> Ketoconazole Tablets

Relevance: 22.07.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using ketoconazole together with atropine may decrease the effects of ketoconazole. Atropine should be administered at least 2 hours after ketoconazole. Contact your doctor if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSING INTERVAL: Theoretically, anticholinergic agents can reduce gastric acid secretion and reduce the oral bioavailability of ketoconazole, which requires an acidic environment for dissolution and absorption.

MANAGEMENT: Anticholinergic agents should be administered at least 2 hours after ketoconazole.

References

"Product Information. Nizoral (ketoconazole)." Janssen Pharmaceutica, Titusville, NJ.

Atropine injection

Generic Name: atropine

Brand name: Sal-Tropine, AtroPen, Atreza

Synonyms: Atropine (injection), Atropine (Systemic)

What is Atropine injection?

Ketoconazole Tablets

Generic Name: ketoconazole

Brand name: Nizoral

Synonyms: Ketoconazole, Ketoconazole (Systemic)

What is Ketoconazole Tablets?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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