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Atropine injection and Propulsid (Cisapride Suspension)

Determining the interaction of Atropine injection and Propulsid (Cisapride Suspension) and the possibility of their joint administration.

Check result:
Atropine injection <> Propulsid (Cisapride Suspension)
Relevance: 22.07.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Cisapride in no longer on the market in the US. Do not take cisapride with any other medication.

Professional:

GENERALLY AVOID: Concomitant administration of anticholinergic agents would be expected to compromise the beneficial effects of cisapride. Cisapride enhances the release of acetylcholine to produce increased gastrointestinal motility. Anticholinergic agents by blocking this action could delay gastric emptying and worsen esophageal reflux.

MANAGEMENT: This combination should be avoided.

References
  • "Product Information. Propulsid (cisapride)." Janssen Pharmaceutica, Titusville, NJ.
Atropine injection

Generic Name: atropine

Brand name: Sal-Tropine, AtroPen, Atreza

Synonyms: Atropine (injection), Atropine (Systemic)

Propulsid (Cisapride Suspension)

Generic Name: cisapride

Brand name: Propulsid

Synonyms: Propulsid (Suspension), Propulsid

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.