Atropine Sulfate eent and Cyproheptadine Hydrochloride

• Generic Name: atropine ophthalmic
• Dosage Forms: n.a.
• Other Brand Names: Atropine-1, Isopto Atropine, Atropisol, Ocu-Tropine, Atropine Care, Atrosulf-1, Atropin-Care

Used to produce mydriasis and cycloplegia for refraction (e.g., retina and optic disc examination, measurement of refractive error). However, because of long duration of action relative to that of other anticholinergic agents, atropine is seldom, if ever, used for cycloplegic refraction in adults.

In rare cases, ophthalmic atropine use may be necessary to achieve maximal cycloplegia in pediatric patients, but cyclopentolate is more frequently used.

Management of acute inflammatory conditions (e.g., iridocyclitis) of the iris and uveal tract (e.g., uveitis).

Used for cycloplegic effects in the treatment of suppression amblyopia (lazy eye) to reduce the visual acuity of the unaffected eye below that of the amblyopic one and force fixation with the amblyopic eye.

Used to treat patients with a functional excess of accommodation and convergence.

• Generic Name: cyproheptadine
• Dosage Forms: n.a.
• Other Brand Names:

  Periactin

Treatment of cold urticaria.

Symptomatic relief of perennial (nonseasonal) and seasonal (e.g., hay fever) allergic rhinitis.

Management of nonallergic (vasomotor) rhinitis.

Management of allergic conjunctivitis caused by foods or inhaled allergens.

Management of mild, uncomplicated allergic skin manifestations of urticaria and angioedema.

Treatment of dermatographism.

Amelioration of allergic reactions to blood or plasma.

Adjunct to epinephrine and other standard measures for management of anaphylactic reactions after acute manifestations have been controlled.

Has been effective in some patients for the treatment of Cushing’s syndrome secondary to pituitary disorders; however, in most patients, other therapy (e.g., surgery, radiation therapy) is preferred.

Has been effective for the management of inhibited male or female orgasm (anorgasmy) induced by tricyclic antidepressants, MAO inhibitors, fluoxetine, or antipsychotic agents. However, consider the potential for interactions between these drugs and cyproheptadine. (See Interactions.)

Has been shown to stimulate appetite and weight gain in children and adults; however, few indications for clinical use. May be of some value in the treatment of anorexia nervosa; may be more effective in nonbulimic patients than in those who are bulimic.

Reportedly has been effective in some patients for the management of vascular headaches (e.g., migraine). Efficacy for prophylaxis of migraine not established in randomized controlled studies, but some experts consider the drug to be effective based on consensus and clinical experience.