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Auranofin and Dilantin

Determining the interaction of Auranofin and Dilantin and the possibility of their joint administration.

Check result:
Auranofin <> Dilantin
Relevance: 16.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Data from a single case report suggest that auranofin may increase serum phenytoin concentrations. The mechanism and clinical significance are unknown. More data are needed to verify this interaction. Patients should be advised to notify their physician if they experience symptoms of phenytoin toxicity (e.g., drowsiness, visual disturbances, change in mental status, nausea, or ataxia).

References
  • "Product Information. Ridaura (auranofin)." SmithKline Beecham, Philadelphia, PA.
Auranofin

Generic Name: auranofin

Brand name: Ridaura

Synonyms: n.a.

Dilantin

Generic Name: phenytoin

Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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