Austedo and Reserpine, hydralazine, and hydrochlorothiazide

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using deutetrabenazine together with reserpine is not recommended. These medications have similar effects and taking them together can increase the risk of serious side effects. When switching from reserpine to deutetrabenazine, you need to wait at least 20 days after stopping reserpine before starting deutetrabenazine. Call your doctor if you experience depression, suicidal thoughts, anxiety, restlessness, excessive drowsiness, or symptoms of parkinsonism such as slight shaking, body stiffness, trouble moving, or keeping your balance. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

CONTRAINDICATED: Reserpine, tetrabenazine, and deutetrabenazine are monoamine depletors and may have additive effects during coadministration. Reserpine binds irreversibly to human vesicular monoamine transporter type 2 (VMAT2), and the duration of its effect is several days. Tetrabenazine, deutetrabenazine and their active metabolites are reversible VMAT2 inhibitors. Overdosage and severe monoamine depletion in the central nervous system may occur when switching from reserpine to either tetrabenazine or deutetrabenazine if reserpine is not sufficiently cleared from the body before either of these medications is initiated. Presynaptic dopamine depletion could theoretically lead to supersensitivity to dopamine and increase the risk of tardive dyskinesia, which is a potentially irreversible syndrome of involuntary dyskinetic movements. The risk of other movement and motility disorders such as parkinsonism, dysphagia, akathisia, and other extrapyramidal symptoms may also be increased. Over-depletion of serotonin and norepinephrine may increase the risk of depression and suicidality.

MANAGEMENT: Concomitant use of reserpine with either tetrabenazine or deutetrabenazine is considered contraindicated. Caution should be exercised when switching from reserpine to either medication. At least 20 days should elapse after stopping reserpine before initiating therapy with either tetrabenazine or deutetrabenazine. The physician is advised to wait for chorea to reemerge before administering tetrabenazine or deutetrabenazine to avoid monoamine over-depletion in the central nervous system.

Austedo

Generic Name: deutetrabenazine

Brand name: Austedo

Synonyms: n.a.

What is Austedo?

Reserpine, hydralazine, and hydrochlorothiazide

Generic Name: hydralazine / hydrochlorothiazide / reserpine

Brand name:

Synonyms: Reserpine, hydralazine, and hydrochlorothiazide (Oral)

What is Reserpine, hydralazine, and hydrochlorothiazide?