Austedo and Xenazine

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using tetrabenazine together with deutetrabenazine is not recommended. These medications have similar effects and taking them together can increase the risk of serious side effects. You may start taking deutetrabenazine the day after stopping tetrabenazine at the dose prescribed by your doctor. Call your doctor if you experience depression, suicidal thoughts, anxiety, restlessness, excessive drowsiness, or symptoms of parkinsonism such as slight shaking, body stiffness, trouble moving or keeping your balance. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

CONTRAINDICATED: Tetrabenazine and deutetrabenazine and their active metabolites are reversible depletors of monoamine neurotransmitters and may have additive effects during coadministration. Both medications are reversible inhibitors of the human vesicular monoamine transporter type 2 (VMAT2), which is responsible for the monoamine transport from cellular cytosol into the synaptic vesicles. Severe monoamine depletion in the central nervous system may occur if these medications are given together. Presynaptic dopamine over-depletion could theoretically lead to supersensitivity to dopamine and increase the risk of tardive dyskinesia, which is a potentially irreversible syndrome of involuntary dyskinetic movements. The risk of other movement and motility disorders such as parkinsonism, dysphagia, akathisia, and other extrapyramidal symptoms may also be increased. Over-depletion of serotonin and norepinephrine may increase the risk of depression and suicidality.

MANAGEMENT: Concomitant use of tetrabenazine and deutetrabenazine is considered contraindicated. Treatment with deutetrabenazine may be started the day following discontinuation of tetrabenazine. The manufacturer's product labeling should be consulted for dosing guidelines when switching from tetrabenazine to deutetrabenazine.

Austedo

Generic Name: deutetrabenazine

Brand name: Austedo

Synonyms: n.a.

What is Austedo?

Xenazine

Generic Name: tetrabenazine

Brand name: Xenazine

Synonyms: n.a.

What is Xenazine?