Avage Topical and Rosiglitazone Maleate

• Generic Name: tazarotene topical
• Dosage Forms: cream
• Other Brand Names: Avage, Fabior, Tazorac

Tazarotene topical foam and gel are used to treat acne. This medicine works to help clear acne on the face partly by keeping the skin pores clear (tiny openings on the skin).

Tazarotene topical 0.1% cream is used to help reduce fine facial wrinkles and certain types of dark and light spots on the face in patients who use a total skin care program and avoid sunlight.

Tazarotene topical cream and gel are used to treat psoriasis. Tazorac® gel is used to treat plaque psoriasis in up to 20% of the skin area involved. This medicine works by making the skin less red and reducing the number and size of lesions of the skin.

This medicine is available only with your doctor's prescription.

• Generic Name: rosiglitazone
• Dosage Forms: n.a.
• Other Brand Names: Avandia

Used as monotherapy or in combination with a sulfonylurea, metformin, or a sulfonylurea and metformin as an adjunct to diet and exercise for the management of type 2 (noninsulin-dependent) diabetes mellitus (NIDDM).

May be added to glyburide/metformin fixed-combination therapy if hyperglycemia is not adequately controlled with the fixed combination.

May be used in combination with repaglinide if hyperglycemia is not adequately controlled with repaglinide monotherapy.

May use fixed combination of rosiglitazone/metformin (Avandamet) when treatment with rosiglitazone and metformin is appropriate.

May use fixed combination of rosiglitazone/glimepiride (Avandaryl) when treatment with rosiglitazone and glimepiride is appropriate.

Metformin is the preferred initial oral antidiabetic agent for patients with type 2 diabetes mellitus. Thiazolidinediones are one of several second-line agents used with other oral antidiabetic agents (e.g., metformin) in patients who are inadequately controlled on their current oral therapy. Because of potential for serious adverse effects, American Diabetes Association (ADA) recommends that clinicians carefully weigh the potential risks and benefits of thiazolidinediones versus other second-line agents (i.e., insulin, sulfonylureas).

Use in combination with insulin not recommended.

Because endogenous insulin is required for activity, not indicated for type 1 diabetes mellitus or diabetic ketoacidosis.