Avanafil and Fedratinib

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this interaction is not currently available.ADJUST DOSE: Coadministration with moderate inhibitors of CYP450 3A4 may increase the plasma concentrations of avanafil, which is primarily metabolized by the isoenzyme. In 15 healthy male volunteers, administration of a single 200 mg dose of avanafil following pretreatment with the moderate CYP450 3A4 inhibitor erythromycin (500 mg twice daily for 5 days) increased avanafil peak plasma concentration (Cmax) and systemic exposure (AUC) by approximately 2-fold and 3.6-fold, respectively, compared to administration of avanafil alone. Erythromycin also prolonged the half-life of avanafil to approximately 8 hours, from a normal of 5 hours. MANAGEMENT: The dosage of avanafil should not exceed 50 mg once every 24 hours when used in combination with moderate CYP450 3A4 inhibitors. References "Product Information. Stendra (avanafil)." Vivus Inc, Mountain View, CA.

ADJUST DOSE: Coadministration with moderate inhibitors of CYP450 3A4 may increase the plasma concentrations of avanafil, which is primarily metabolized by the isoenzyme. In 15 healthy male volunteers, administration of a single 200 mg dose of avanafil following pretreatment with the moderate CYP450 3A4 inhibitor erythromycin (500 mg twice daily for 5 days) increased avanafil peak plasma concentration (Cmax) and systemic exposure (AUC) by approximately 2-fold and 3.6-fold, respectively, compared to administration of avanafil alone. Erythromycin also prolonged the half-life of avanafil to approximately 8 hours, from a normal of 5 hours.

MANAGEMENT: The dosage of avanafil should not exceed 50 mg once every 24 hours when used in combination with moderate CYP450 3A4 inhibitors.

Avanafil

Generic Name: avanafil

Brand name: Stendra

Synonyms: n.a.

What is Avanafil?

Fedratinib

Generic Name: fedratinib

Brand name: Inrebic

Synonyms: n.a.

What is Fedratinib?