Avandaryl and Luvox

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using fluvoxaMINE together with glimepiride can increase the effects of glimepiride. You should be advised to regularly monitor your blood sugar and counseled on how to recognize and treat hypoglycemia (low blood sugar), which may include symptoms such as headache, dizziness, drowsiness, nervousness, confusion, tremor, hunger, weakness, perspiration, and palpitations. You may need a dose adjustment or blood sugar checked more often to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: The coadministration with fluvoxamine may increase the plasma concentrations of glimepiride. The mechanism probably involves increased absorption of glimepiride and/or decreased clearance due to inhibition of the CYP450 2C9 enzymatic pathway by fluvoxamine. In a randomized, placebo-controlled, crossover study consisting of 12 healthy subjects, fluvoxamine (100 mg orally daily for 4 days) increased the peak plasma concentration (Cmax) of a single dose of glimepiride (0.5 mg) by 43%. The elimination half-life was prolonged from 2 to 2.3 hours, while the area under the concentration-time curve (AUC) was not significantly affected. Fluvoxamine also did not alter the effects of glimepiride on blood glucose levels.

MANAGEMENT: As a precaution, it may be appropriate to monitor blood glucose more closely during the concomitant use of glimepiride and fluvoxamine, and adjust the glimepiride dosage if necessary. Patients should be counseled to recognize the signs of hypoglycemia (e.g., headache, dizziness, drowsiness, nausea, tremor, weakness, or palpitations) and how to treat it.

Avandaryl

Generic Name: glimepiride / rosiglitazone

Brand name: Avandaryl

Synonyms: n.a.

What is Avandaryl?

Luvox

Generic Name: fluvoxamine

Brand name: Luvox, Luvox CR

Synonyms: n.a.

What is Luvox?