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Avandaryl and Phenobarbital Elixir

Determining the interaction of Avandaryl and Phenobarbital Elixir and the possibility of their joint administration.

Check result:

Avandaryl <> Phenobarbital Elixir

Relevance: 16.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

PHENobarbital may reduce the blood levels and effects of rosiglitazone. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring of your blood sugar to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with inducers of CYP450 2C8 may decrease the plasma concentrations of rosiglitazone, which is primarily metabolized by the isoenzyme. In 10 healthy volunteers given the potent enzyme inducer rifampin (600 mg once daily) for six days prior to coadministration with a single 8 mg dose of rosiglitazone on day 7, mean rosiglitazone peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by 31% and 66%, respectively, while elimination half-life decreased from 3.9 to 1.5 hours. Apparent oral clearance of rosiglitazone increased about 3-fold with rifampin pretreatment. These changes were observed in every subject. Similar results were reported for rosiglitazone 4 mg in another pharmacokinetic study.

MANAGEMENT: Because the antidiabetic effect of rosiglitazone is dose- and concentration-dependent, patients treated concomitantly with a CYP450 2C8 inducer may require a higher dosage of rosiglitazone. Close clinical monitoring of glycemic control is recommended following initiation or discontinuation of the CYP450 2C8 inducer, and the rosiglitazone dosage adjusted as necessary.

References

Scheen AJ "Pharmacokinetic interactions with thiazolidinediones." Clin Pharmacokinet 46 (2007): 1-12
"Product Information. Avandia (rosiglitazone)" SmithKline Beecham, Philadelphia, PA.
Baldwin SJ, Clarke SE, Chenery RJ "Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of rosiglitazone." Br J Clin Pharmacol 48 (1999): 424-32
Park JY, Kim KA, Kang MH, Kim SL, Shin JG "Effect of rifampin on the pharmacokinetics of rosiglitazone in healthy subjects." Clin Pharmacol Ther 75 (2004): 157-62
Totah RA, Rettie AE "Cytochrome P450 2C8: substrates, inhibitors, pharmacogenetics, and clinical relevance." Clin Pharmacol Ther 77 (2005): 341-52
Niemi M, Backman JT, Neuvonen PJ "Effects of trimethoprim and rifampin on the pharmacokinetics of the cytochrome P450 2C8 substrate rosiglitazone." Clin Pharmacol Ther 76 (2004): 239-49

Avandaryl

Generic Name: glimepiride / rosiglitazone

Brand name: Avandaryl

Synonyms: n.a.

What is Avandaryl?

Phenobarbital Elixir

Generic Name: phenobarbital

Brand name: Solfoton, Luminal

Synonyms: Phenobarbital, PHENobarbital

What is Phenobarbital Elixir?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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