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Avapro and Procardia XL

Determining the interaction of Avapro and Procardia XL and the possibility of their joint administration.

Check result:

Avapro <> Procardia XL

Relevance: 24.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

In vitro studies have shown significant inhibition of the formation of oxidized irbesartan metabolites when given concomitantly with the known 2C9 substrate/inhibitors tolbutamide and nifedipine. However, in clinical studies, the pharmacokinetics and pharmacodynamics of irbesartan were not significantly affected. No special precautions appear necessary.

References

"Product Information. Avapro (irbesartan)." Bristol-Myers Squibb, Princeton, NJ.
Marino MR, Vachharajani NN "Drug interactions with irbesartan." Clin Pharmacokinet 40 (2001): 605-14

Avapro

Generic Name: irbesartan

Brand name: Avapro

Synonyms: n.a.

What is Avapro?

Procardia XL

Generic Name: nifedipine

Brand name: Adalat CC, Procardia, Procardia XL, Afeditab CR, Nifediac CC, Nifedical XL, Adalat

Synonyms: n.a.

What is Procardia XL?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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