Avelox (Moxifloxacin Tablets) and Hycamtin Capsules
Determining the interaction of Avelox (Moxifloxacin Tablets) and Hycamtin Capsules and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Limited data suggest that chemotherapy with antineoplastic agents may reduce the plasma concentrations of oral quinolone antibiotics. The proposed mechanism is decreased quinolone absorption secondary to alteration of intestinal mucosa by cancer chemotherapy. In six patients with newly diagnosed hematologic malignancy, treatment with various antineoplastic agents (cyclophosphamide, cytarabine, daunorubicin, doxorubicin, mitoxantrone, prednisolone, vincristine) decreased the mean peak serum concentration (Cmax) and area under the concentration-time curve (AUC 0 to 4 hours) of ciprofloxacin by approximately 46% each. Data are not available for other quinolone antibiotics.
- Johnson EJ, MacGowan AP, Potter MN, et al "Reduced absorption of oral ciprofloxacin after chemotherapy for haematological malignancy." J Antimicrob Chemother 25 (1990): 837-42
Generic Name: moxifloxacin
Brand name: Avelox, Avelox IV
Synonyms: Avelox
Generic Name: topotecan
Brand name: Hycamtin
Synonyms: Topotecan (oral/injection), Topotecan
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Avelox (Moxifloxacin Tablets)-Hycamtin Intravenous
- Avelox (Moxifloxacin Tablets)-Hycamtin oral/injection
- Avelox (Moxifloxacin Tablets)-Hycet
- Avelox (Moxifloxacin Tablets)-Hycodan
- Avelox (Moxifloxacin Tablets)-Hycodan Oral
- Avelox (Moxifloxacin Tablets)-Hycodan Oral Solution
- Hycamtin Capsules-Avelox ABC Pack
- Hycamtin Capsules-Avelox I.V.
- Hycamtin Capsules-Avelox Injection
- Hycamtin Capsules-Avelumab
- Hycamtin Capsules-Avelumab Intravenous
- Hycamtin Capsules-Aventyl