Axid Oral Solution and Nerlynx

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

By reducing the acidity level in the stomach, raNITIdine may interfere with the absorption of neratinib and reduce its effectiveness. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact or interact to a lesser extent. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration with proton pump inhibitors or H2-receptor antagonists may significantly decrease the oral bioavailability of neratinib. The solubility of neratinib is pH-dependent and increases as neratinib becomes protonated at acidic pH, thus an increase in pH may interfere with its absorption. According to the product labeling, neratinib is sparingly soluble at pH 1.2 (32.90 mg/mL) and insoluble at approximate pH 5.0 and above (0.08 mg/mL or less). When a single 240 mg dose of neratinib was administered to 15 healthy adult subjects on day 5 of treatment with lansoprazole 30 mg orally once daily for 7 days, mean neratinib peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by 71% and 65%, respectively, compared to neratinib administered alone. In addition, the Cmax and AUC of neratinib were reduced by 55% and 47%, respectively, when neratinib was administered 2 hours after a 300 mg dose of ranitidine.

MANAGEMENT: Concomitant use of neratinib with proton pump inhibitors and H2-receptor antagonists should generally be avoided. According to some authorities, if H2-receptor antagonist therapy is required, neratinib should be administered at least 2 hours before or 10 hours after the H2-receptor antagonist. In addition, short-acting antacids could be considered if acid-suppression therapy is required, with neratinib dosing separated by at least three hours after antacid administration. If coadministered with a gastric acid reducing agent, increasing the dose of neratinib is unlikely to compensate for the loss of bioavailability.

Axid Oral Solution

Generic Name: nizatidine

Brand name: Baciguent, Probiotic Formula, Proferrin-ES

Synonyms: n.a.

What is Axid Oral Solution?

Nerlynx

Generic Name: neratinib

Brand name: Nerlynx

Synonyms: n.a.

What is Nerlynx?