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Axid Oral Solution and Pradaxa

Determining the interaction of Axid Oral Solution and Pradaxa and the possibility of their joint administration.

Check result:

Axid Oral Solution <> Pradaxa

Relevance: 16.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Talk to your doctor before using dabigatran if you are receiving raNITIdine for a gastrointestinal condition such as stomach ulcer or bleeding. Treatment with dabigatran may worsen your symptoms and increase the risk of bleeding. Contact your doctor if you experience potential signs and symptoms of bleeding such as dizziness; lightheadedness; red or black stools; coughing up or vomiting blood or blood clots; and abdominal pain. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Patients with gastrointestinal conditions may have an increased risk of gastrointestinal bleeding during concomitant treatment with dabigatran etexilate and proton pump inhibitors or H2 blockers. In addition, pantoprazole resulted in an approximately 30% decrease in dabigatran systemic exposure (AUC). Diminished clinical effect may occur, although no dosage adjustment is recommended for dabigatran etexilate. The pharmacokinetics of pantoprazole were not significantly altered by dabigatran. Pantoprazole and other proton pump inhibitors were also coadministered with dabigatran in clinical trials for the prevention of venous thromboembolic events after hip- or knee-replacement surgery, and no effects on bleeding or efficacy were observed. Ranitidine had no significant effects on the absorption of dabigatran.

MANAGEMENT: Patients should be monitored for signs of gastrointestinal bleeding and advised to promptly report any symptoms to their physician, such as abdominal pain, dizziness, lightheadedness, vomiting blood, anorexia, and/or black, tarry stools.

References

Cerner Multum, Inc. "Australian Product Information." O 0
"Product Information. Pradax (dabigatran)." Boehringer Ingelheim (Canada) Ltd, Burlington, IA.
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
"Product Information. Pradaxa (dabigatran)." Boehringer-Ingelheim, Ridgefield, CT.

Axid Oral Solution

Generic Name: nizatidine

Brand name: Baciguent, Probiotic Formula, Proferrin-ES

Synonyms: n.a.

What is Axid Oral Solution?

Pradaxa

Generic Name: dabigatran

Brand name: Pradaxa

Synonyms: n.a.

What is Pradaxa?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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