Axid Oral Solution and Sprycel

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using dasatinib together with raNITIdine is generally not recommended. RaNITIdine may interfere with the absorption of dasatinib into the bloodstream, which may make the medication less effective in treating your cancer. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Nonclinical data indicate that the solubility of dasatinib is pH-dependent. Therefore, long-term suppression of gastric acid secretion by H2-receptor antagonists or proton pump inhibitors is likely to reduce dasatinib systemic exposure. In 24 healthy study subjects, administration of a 50 mg dose of dasatinib 10 hours after famotidine was associated with an approximately 60% reduction in dasatinib peak plasma concentration (Cmax) and systemic exposure (AUC). In 14 healthy study subjects, administration of a single 100 mg dose of dasatinib 22 hours following a 40 mg dose of omeprazole at steady state reduced the Cmax and AUC of dasatinib by over 40% each.

MANAGEMENT: Concomitant use of dasatinib with H2-receptor antagonists or proton pump inhibitors is not recommended. If gastric acidity management is necessary, antacids should be considered in place of these agents. However, patients treated with dasatinib should avoid taking antacids or oral medications that contain antacids (e.g., didanosine buffered tablets or pediatric oral solution) for at least two hours before and two hours after administration of dasatinib.

Axid Oral Solution

Generic Name: nizatidine

Brand name: Baciguent, Probiotic Formula, Proferrin-ES

Synonyms: n.a.

What is Axid Oral Solution?

Sprycel

Generic Name: dasatinib

Brand name: Sprycel

Synonyms: n.a.

What is Sprycel?