Axitinib and Famotidine Chewable Tablets
Determining the interaction of Axitinib and Famotidine Chewable Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Since the aqueous solubility of axitinib is pH-dependent, with higher pH resulting in lower solubility, drugs that increase the pH of the upper gastrointestinal tract may reduce the oral bioavailability of axitinib. The interaction has been studied with rabeprazole. When given with rabeprazole (20 mg once daily for 5 days), axitinib peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by approximately 50% and 20%, respectively. These changes are not considered clinically significant. No dosage adjustment for axitinib is recommended during coadministration with proton pump inhibitors, H2-receptor antagonists, or antacids.
- "Product Information. Inlyta (axitinib)." Pfizer U.S. Pharmaceuticals Group, New York, NY.
Generic Name: famotidine
Brand name: Pepcid, Heartburn Relief, Pepcid AC, Pepcid AC Maximum Strength, Pepcid AC Chewable Tablets, Pepcid Oral Suspension
Synonyms: Famotidine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Axitinib-Famotidine Injection
- Axitinib-Famotidine Injection Solution
- Axitinib-Famotidine Oral Suspension
- Axitinib-Famotidine Tablets
- Axitinib-Famotidine, Calcium Carbonate, and Magnesium Hydroxide
- Axitinib-Famvir
- Famotidine Chewable Tablets-Axsain
- Famotidine Chewable Tablets-Aygestin
- Famotidine Chewable Tablets-Ayuna
- Famotidine Chewable Tablets-Azacitidine
- Famotidine Chewable Tablets-Azacitidine Injection
- Famotidine Chewable Tablets-Azacitidine Subcutaneous