Axitinib and Pedia-Lax Chewable
Determining the interaction of Axitinib and Pedia-Lax Chewable and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Since the aqueous solubility of axitinib is pH-dependent, with higher pH resulting in lower solubility, drugs that increase the pH of the upper gastrointestinal tract may reduce the oral bioavailability of axitinib. The interaction has been studied with rabeprazole. When given with rabeprazole (20 mg once daily for 5 days), axitinib peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by approximately 50% and 20%, respectively. These changes are not considered clinically significant. No dosage adjustment for axitinib is recommended during coadministration with proton pump inhibitors, H2-receptor antagonists, or antacids.
- "Product Information. Inlyta (axitinib)." Pfizer U.S. Pharmaceuticals Group, New York, NY.
Generic Name: magnesium hydroxide
Brand name: Ex-Lax Milk of Magnesia, Milk of Magnesia, Pedia-Lax Chewable, Phillips Milk of Magnesia, Dulcolax Milk of Magnesia, Concentrated Phillips Milk of Magnesia
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Axitinib-Pedia-Lax Liquid rectal
- Axitinib-Pediacare
- Axitinib-PediaCare Children’s Multi-Symptom
- Axitinib-PediaCare Cold/Allergy
- Axitinib-Pediacare Decongestant Infants
- Axitinib-Pediacare Long-Acting Cough
- Pedia-Lax Chewable-Axsain
- Pedia-Lax Chewable-Aygestin
- Pedia-Lax Chewable-Ayuna
- Pedia-Lax Chewable-Azacitidine
- Pedia-Lax Chewable-Azacitidine Injection
- Pedia-Lax Chewable-Azacitidine Subcutaneous