Azathioprine Oral, Intravenous and Febuxostat

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using azaTHIOprine together with febuxostat is not recommended. Febuxostat can increase the blood levels of azaTHIOprine, possibly to toxic levels. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

CONTRAINDICATED: Coadministration with febuxostat may significantly increase the plasma concentrations of xanthine oxidase substrates such as azathioprine, mercaptopurine, and theophylline. Toxicity may result. The proposed mechanism is inhibition of xanthine oxidase by febuxostat. Although drug interaction studies have not been conducted with febuxostat and xanthine oxidase substrates, the interaction has been reported with allopurinol, another xanthine oxidase inhibitor. Severe bone marrow suppression and other toxicities have been associated with concomitant use of allopurinol and mercaptopurine (6-MP) or azathioprine. Increased theophylline concentrations have also been reported during coadministration with allopurinol at dosages of 600 mg/day or greater.

MANAGEMENT: The use of febuxostat in patients treated with azathioprine, mercaptopurine, or theophylline is considered contraindicated.

Azathioprine Oral, Intravenous

Generic Name: azathioprine

Brand name: Azasan, Imuran

Synonyms: Azathioprine, AzaTHIOprine

What is Azathioprine Oral, Intravenous?

Febuxostat

Generic Name: febuxostat

Brand name: Uloric

Synonyms: n.a.

What is Febuxostat?